Isolation and Characterization of Mycoplasmas (pplo) from Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Reiter's Syndrome.

Using tissue culture methods, mycoplasmas (PPLO) were isolated from synovial fluid, bone marrow, kidney, or serum of 14 of 17 patients with either rheumatoid arthritis, systemic lupus erythematosus, or Reiter's syndrome. Sensitivity to various antibiotics and the ability to ferment glucose varied, but all strains were sensitive to tetracycline, and hemolysed sheep cells. Antigenic relationships, studied by complement fixation and growth inhibition, revealed minor differences among the strains, except one which appeared culturally and antigenically distinct. Growth inhibition agzinst several recognized human mycoplzsmas was demonstrated. Con le utilisation de methodos histocultural, mycoplasmas ( PPLO-organismos pleuropneumonia-simile) esseva isolate ah liquid0 synovial, medulla ossee, ren, o sero in 14 de 17 patientes con arthritis rheumatoide, disseminate lupus erythematose, o syndrome de Reiter. Le sensibilitate pro varie antibioticos e le capacitate de fermentar glucosa variava ah un linea a1 altere, sed omnes esseva sensibile pro tetracyclina, e omnes hemolysava cellulas ovin. Le relationes antigenic, studiate per tests a fixation de complemento e inhibition de crescentia, revelava solmente minor differentias inter le lineas, con le exception de un sol. Isto pareva esser culturalmente e antigenicamente distincte. Esseva demonstrate inhibition de crescentia contra plure recognoscite mycoplasmas human.